POLY(MALEIC ANHYDRIDE-CO-ACRYLIC ACID)/POLY(ETHYLENE GLYCOL) HYDROGELS WITH pH-AND IONIC-STRENGTH-RESPONSES

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Poly(maleic anhydride-co-acrylic acid),P(MA-AA),was synthesized by the free-radical copolymerization of maleic anhydride with acrylic acid,and fast responsive pH-sensitive poly(maleic anhydride-co-acrylic acid)/polyethylene glycol,P(MA-AA)/PEG,hydrogels were prepared using PEG as macromolecular cross-linking agent.FT-IR and 1H-NMR spectrometry were applied to characterize the structure of P(MA-AA).The influences of pH and ionic strength on the swelling behavior of P(MA-AA)/PEG hydrogels and the swelling-deswelling changes along with the repeated changes between acid and alkali conditions were studied.The results showed that there was a hundredfold difference in the swelling ratios between the conditions of acid and alkali,and the swelling capability could not be weakened after multiple swellingdeswelling cycles.The results of swelling kinetics demonstrated that the response rate of P(MA-AA)/PEG hydrogels was very fast,because the swelling transition points always occurred at 10 min.The pH-responsive hydrogels reported here might be a smart material for potentially applications in many areas,including biosensors,drug-delivery devices and tissue engineering.

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DOI: http://dx.doi.org/10.1007/s10118-010-9191-x

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