厚朴化学成分和药理作用研究概况

殷帅文 已出版文章查询
殷帅文
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shwyin@jgsu.edu.cn
1 何旭梅 已出版文章查询
何旭梅
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1 郎锋祥 已出版文章查询
郎锋祥
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1 肖宜安 已出版文章查询
肖宜安
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1井冈山学院,生命科学学院,江西,吉安,343009


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对常用中药厚朴的化学成分及抑菌、抗肿瘤、抗炎、抗凝血、抗溃疡、心脑血管、酶系统等药理作用研究进行了综述,在此基础上对其未来研究方向进行了探讨.

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[3] 王立青,江荣高,陈蕙芳.厚朴酚与和厚朴酚药理作用的研究进展[J].中草药,2005(10):1591-1594.

[4] 邓世明,程永现,周俊,谭宁华,丁中涛.长缘厚朴中的新苯醌及新木脂素类化合物[J].云南植物研究,2001(01):121-125.

[5] 杨云;张晶;陈玉婷.天然药物化学成分提取分离手册[M].北京:中国中医药出版社,2003:540-542.

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[7] 叶华,张文清,邱燕.厚朴花挥发油的GC-MS联用分析[J].福建中医药,2006(06):53-54.

[8] 王洪燕,周先礼,黄帅,申向黎.凹叶厚朴中生物碱成分的研究[J].华西药学杂志,2007(01):30-33.

[9] Pyo MK;Yun Choi HS;Hong YJ .Antiplatelet Activities of Aporphine Alkaloids Isolated from Leaves of Magnolia obovata.[J].Planta medica: Natural products and medicinal plant research,2003(3):267-269.

[10] 龙飞 .厚朴资源综合利用研究——厚朴叶药用价值的初步研究[D].成都中医药大学,2006.

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[12] 冯瑾,李继遥,周学东.厚朴活性成分对致龋菌生长和产酸影响的体外研究[J].四川大学学报(医学版),2007(03):456-458.

[13] Ho KY;Tsai CC;Chen CP et al.Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis[J].Phytotherapy Research,2001,15(02):139-141.

[14] Park J;Lee J;Jung E;Park Y;Kim K;Park B;Jung K;Park E;Kim J;Park D .In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.[J].European Journal of Pharmacology: An International Journal,2004(1/3):189-195.

[15] 林桂芸,谢生发,谢鸿,鸥俊.和厚朴酚抑菌作用的研究[J].成都大学学报(自然科学版),2003(02):18-20.

[16] Bai X;Cerimele F;Ushio Fukai M;Waqas M;Campbell PM;Govindarajan B;Der CJ;Battle T;Frank DA;Ye K;Murad E;Dubiel W;Soff G;Arbiser JL .Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.[J].The Journal of biological chemistry,2003(37):35501-35507.

[17] Shu-Er Yang;Ming-Tsuen Hsieh;Tung-Hu Tsai;Shih-Lan Hsu .Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells[J].British Journal of Pharmacology,2003(1):193-201.

[18] Lin SY;Liu JD;Chang HC et al.Magnololsuppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apotosis[J].Journal of Cellular Biochemistry,2002,84(03):532-544.

[19] Ishitsuka K;Hideshima T;Hamasaki M;Raje N;Kumar S;Hideshima H;Shiraishi N;Yasui H;Roccaro AM;Richardson P;Podar K;Le Gouill S;Chauhan D;Tamura K;Arbiser J;Anderson KC .Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.[J].Blood,2005(5):1794-1800.

[20] Wang C .Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D(3) and retinoic acid.[J].The international journal of biochemistry & cell biology,2005(2):427-441.

[21] Wan-Jr Syu;Chien-Chang Shen;Jang-Jih Lu;Gum-Hee Lee;Chang-Ming Sun .Antimicrobial and Cytotoxic Activities of Neolignans from Magnolia officinalis[J].Chemistry & biodiversity,2004(3):530-537.

[22] Wang JP;Ho TF;Chang LC et al.Anti-inflammatory effect of magnolol,isolated from Magnolia officinalis,on A23187-induced pleurisy in mice[J].Journal of Pharmacy and Pharmacology,1995,47(10):857-860.

[23] 李杰萍,梁统,周克元.厚朴酚对趋化三肽激活的大鼠中性粒细胞功能的影响[J].中国药科大学学报,2003(03):260-263.

[24] Chiu JH.;Wei YH.;Lui WY.;Hong CY.;Ho CT. .IN VITRO AND IN VIVO PROTECTIVE EFFECT OF HONOKIOL ON RAT LIVER FROM PEROXIDATIVE INJURY[J].Life sciences,1997(19):1961-1971.

[25] Lee YM;Hsiao G;Chen HR;Chen YC;Sheu JR;Yen MH .Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats.[J].European Journal of Pharmacology: An International Journal,2001(1/3):159-167.

[26] Huang CH;Hong CY;Tsai SK;Lai ST;Weng ZC;Chih CL;Hsieh YH .Intravenous pretreatment with magnolol protects myocardium against stunning.[J].Planta medica: Natural products and medicinal plant research,2000(6):516-520.

[27] Teng CM;Chen CC;Ko FN et al.Two antiplatelet agents from Magnolia officinalis[J].Thrombosis Research,1988,50(06):757-765.

[28] 张广钦,陈世忠,郝雪梅,程和平,吴才宏.厚朴酚对脑缺血的保护作用[J].中国药理学通报,2003(09):1020-1023.

[29] Liou KT;Shen YC;Chen CF;Tsao CM;Tsai SK .Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production.[J].Brain research,2003(2):159-166.

[30] Teng CM;Chen CC;Ko FN et al.Two antiplatelet agents from Magnolia officinalis[J].Thrombosis Research,1988,50(06):757-765.

[31] Li Y;Xu C;Zhang Q;Liu JY;Tan RX .In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases.[J].Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs,2005(3):329-333.

[32] Kwon BM;Kim MK;lee SH .Acyl-CoA:cholesterol acyltransferase inhibitors from Magnolia obovata[J].Planta Medica,1997,63(06):550-551.


DOI: http://dx.doi.org/10.3969/j.issn.1001-3601.2007.06.048

语种: 中文   

基金江西省教育厅科研项目(赣教技字(2007)327)

关键词厚朴 化学成分 药理作用 研究概况


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