经典型骨肉瘤临床诊疗专家共识的解读

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1100035 北京 北京积水潭医院骨肿瘤科


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为了提高我国经典型骨肉瘤的诊断与治疗水平,制定一个符合我国国情、能在全国范围内实施的规范化诊治共识,中国临床肿瘤学会(CSCO)骨肉瘤专家委员会和中国抗癌协会肉瘤专业委员会组织了骨肉瘤诊治领域的相关专家,以循证医学证据为基础,综合分析并评价了国内外相关文献资料,进行了5次讨论和修订,最终形成了本共识,本文主要是对共识涉及的各相关内容进行解读和分析.

[1] Picci P .Osteosarcoma (osteogenic sarcoma)[J].ORPHANET JOURNAL OF RARE DISEASES,2007,2:6.

[2] Chou AJ;Geller DS;Gorlick R .Therapy for osteosarcoma: where do we go from here?[J].Pediatric drugs,2008(5):315-327.

[3] Meyers PA;Gorlick R .Osteosarcoma.[J].Pediatric clinics of North America,1997(4):973-989.

[4] Ta HT;Dass CR;Choong PF;Dunstan DE .Osteosarcoma treatment: state of the art.[J].Cancer and Metastasis Reviews,2009(1/2):247-263.

[5] 李昕,李建民,杨志平.ⅡB期骨肉瘤临床预后相关因素分析(附40例报告)[J].山东医药,2006(03):6-7.

[6] 谭平先,雍碧城,沈靖南,王晋,尹军强,邹昌业,谢显彪,唐清连,赵志强,黄纲.413例骨肉瘤化疗、手术和预后的10年随访研究[J].中国骨科临床与基础研究杂志,2011(04):256-262.

[7] Ritter J;Bielack SS .Osteosarcoma[J].Annals of Oncology,2010,21(Suppl 7):320-325.

[8] Geller DS;Gorlick R .Osteosarcoma:a review of diagnosis,management,and treatment strategies[J].Clin Adv Hematol Onco1,2010,8(10):705-718.

[9] Messerschmitt PJ;Garcia RM;Abdul Karim FW .Osteosarcoma.[J].The Journal of the American Academy of Orthopaedic Surgeons,2009(8):515-527.

[10] Saeter G .Osteosarcoma:ESMO clinical recommendations for diagnosis,treatment and follow-up[J].Annals of Oncology,2007,18(Suppl 2):77-78.

[11] Marcove RC;Martini N;Rosen G .The treatment of pulmonary metastasis in osteogenic sarcoma[J].Clinical Orthopaedics and Related Research,1975,111:65-70.

[12] Bacci G;Longhi A;Fagioli F;Briccoli A;Versari M;Picci P .Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy.[J].European Journal of Cancer,2005(18):2836-2845.

[13] Taylor WF;Ivins JC;Pritchard DJ et al.Trends and variability in survival among patients with osteosarcoma:a 7-year update[J].Mayo Clinic Proceedings,1985,60(02):91-104.

[14] Taylor WF;Ivins JC;Dahlin DC et al.Trends and variability in survival from osteosarcoma[J].Mayo Clinic Proceedings,1978,53(11):695-700.

[15] Pan KL;Chan WH;Ong GB et al.Limb salvage in osteosarcoma using autoclaved tumor-bearing bone[J].World Journal of Surgical Oncology,2012,10(01):105.

[16] Dunham WK .Osteogenic sarcoma treated with limb salvage[J].Ala Ned,1983,53(05):29-35.

[17] Pochanugool L;Nontasut S;Subhadharaphandou T et al.Multidisciplinary "limb salvage" treatment of osteosarcoma[J].Journal of the Medical Association of Thailand,1991,74(09):404-411.

[18] Bentzen SM .Prognostic factor studies in oncology:osteosarcoma as a clinical example[J].International Journal of Radiation Oncology,Biology,Physics,2001,49(02):513-518.

[19] Raymond AK;Chawla SP;Carrasco CH et al.Osteosarcoma chemotherapy effect:a prognostic factor[J].Seminars in Diagnostic Pathology,1987,4(03):212-236.

[20] Juergens H;Kosloff C;Nirenberg A et al.Prognostic factors in the response of primary osteogenic sarcoma to preoperative chemotherapy (high-dose methotrexate with citrovorum factor)[J].Journal of the National Cancer Institute Monographs,1981,56:221-226.

[21] Harting MT;Lally KP;Andrassy RJ;Vaporciyan AA;Cox CS Jr;Hayes Jordan A;Blakely ML .Age as a prognostic factor for patients with osteosarcoma: an analysis of 438 patients.[J].Journal of Cancer Research and Clinical Oncology,2010(4):561-570.

[22] Sami SH;Rafati AH;Hodjat P .Tissue nccrosis after chcmother apy in osteosarcoma as the important prognostic factor[J].Saudi Medical J,2008,29(08):1124-1129.

[23] Hagleitner MM;Hoogerbrugge PM;van der Graaf WT;Flucke U;Schreuder HW;te Loo DM .Age as prognostic factor in patients with osteosarcoma.[J].Bone,2011(6):1173-1177.

[24] 牛晓辉,王涛,李远,刘文生.骨肉瘤区域淋巴结检查的临床意义[J].中国骨肿瘤骨病,2005(03):131-132,153.

[25] Bakhshi S;Radhakrishnan V .Prognostic markers in osteosarcoma.[J].Expert review of anticancer therapy,2010(2):271-287.

[26] Bramer JA;van Linge JH;Grimer RJ .Prognostic factors in localized extremity osteosarcoma: a systematic review.[J].European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,2009(10):1030-1036.

[27] Bielack S;Jürgens H;Jundt G et al.Osteosarcoma:the COSS experience[J].Cancer Treatment and Research,2009,152:289-308.

[28] Arceci RJ .Response in osteosarcoma.Information you can't use …yet[J].Journal of Pediatric Hematology Oncology,2003,25(11):837-838.

[29] Bielack SS;Kempf Bielack B;Delling G;Exner GU;Flege S;Helmke K;Kotz R;Salzer Kuntschik M;Werner M;Winkelmann W;Zoubek A;Jurgens H;Winkler K .Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.[J].Journal of Clinical Oncology,2002(3):776-790.

[30] Ferguson WS;Goorin AM .Current treatment of osteosarcoma.[J].Cancer investigation,2001(3):292-315.

[31] Kansara, M;Thomas, DM .Molecular pathogenesis of osteosarcoma[J].DNA and Cell Biology,2007(1):1-18.

[32] Wang LL .Biology of osteogenic sarcoma[J].Cancer,2005,11(04):294-305.

[33] Fuchs B;Pritchard DJ .Etiology of osteosarcoma.[J].Clinical Orthopaedics and Related Research,2002(397):40-52.

[34] Finkei M P,Jr;Reilly CA;Biskis BO .Pathogenesis of radiation and virus-induced bone tumors[J].Recent Results in Cancer Research,1976,54:92-103.

[35] Ziewacz JE;Song JW;Blaivas M et al.Radiation-induced meningcal osteosarcoma of tentorium cerebelli with intradural spinal metastases[J].Surg Neuro Int,2010,1:14.

[36] Mavrogenis,A.F.;Pala,E.;Guerra,G.;Ruggieri,P. .Post-radiation sarcomas. Clinical outcome of 52 patients[J].Journal of Surgical Oncology,2012(6):570-576.

[37] Patel AJ;Rao VY;Fox BD;Suki D;Wildrick DM;Sawaya R;DeMonte F .Radiation-induced osteosarcomas of the calvarium and skull base.[J].Cancer: A Journal of the American Cancer Society,2011(10):2120-2126.

[38] Kadota Y;Utsumi T;Inoue M;Sawabata N;Minami M;Okumura M .Radiation-induced osteosarcoma 17 years after mediastinal irradiation following surgical removal of thymoma.[J].General thoracic and cardiovascular surgery,2010(12):651-653.

[39] Franco Gutiérrez V;Llorente Pendá JL;Coca Pelaz A et al.Radiation-induced sarcomas of thc head and neck[J].Journal of Cranio-Maxillofacial Surgery,2008,19(05):1287-1291.

[40] Jaffe N;Traggis D;Cassady JR et al.Multidisciplinary treatment for macrometastatic osteogenic sarcoma[J].British Medical Journal,1976,2(6043):1039-1041.

[41] Jaffe N;Murray J;Traggis D et al.Multidisciplinary treatment for childhood sarcoma[J].American Journal of Surgery,1977,133(04):405-413.

[42] Jr.Douglass HO .Osteosarcoma:survival gains resulting from multidisciplinary therapy[J].Progress in Clinical Cancer,1978,7:83-96.

[43] Calvo FA;Ortiz de Urbina D;Sierrasesumaga L et al.Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents[J].Medical and Pediatric Oncology,1991,19(06):478-485.

[44] Delépine N;Delépine G;Desbois JC et al.Osteogenie osteosarcoma:a model of curable disease by multidisciplinary approach of treatment[J].Biom Pharmacother,1990,44(05):243-248.

[45] Calvo FA;Sierrasesumaga L;Martin I et al.lntraoperative radiotherapy in the multidisciplinary treatment of pediatric tumors.A preliminary report on initial results[J].Acta Oncologica,1989,28(02):257-260.

[46] Federman N;Bernthal N;Eilber FC et al.The multidisciplinary management of osteosarcoma[J].Current Treatment Options in Oncology,2009,10(1-2):82-93.

[47] Jaffe N .Osteosarcoma:review of the past,impact on the future.The American experience[J].Cancer Treatment and Research,2009,152:239-262.

[48] Fletcher BD .Imaging pediatric bone sarcomas. Diagnosis and treatment-related issues.[J].The Radiologic Clinics of North America,1997(6):1477-1494.

[49] Anderson P;Salazar-Abshire M .Improving outcomes in difficult bone cancers using multimodality therapy, including radiation: physician and nursing perspectives.[J].Current oncology reports,2006(6):415-422.

[50] Baeza MR;Barkley HT,Jr;Fernandez CH .Total-lung irradiation in the treatment of pulmonary metastases[J].Radiology,1975,116(01):151-154.

[51] Briccoli A;Rocca M;Salone M;Guzzardella GA;Balladelli A;Bacci G .High grade osteosarcoma of the extremities metastatic to the lung: long-term results in 323 patients treated combining surgery and chemotherapy, 1985-2005.[J].Surgical oncology,2010(4):193-199.

[52] Cupps RE;Ahmann DL;Soule EH .Treatment of pulmonary metastatic disease with radiation therapy and adjuvant actinomycin D.Preliminary observations[J].Cancer,1969,24(04):719-723.

[53] Hamada H;Aoki Y;Yoshikawa H et al.Treatment for osteosarcoma a study of thirty-two patients treated with systemic chemotherapy and radical surgery[J].Nihon Seikeigeka Gakkai Zasshi,1986,60(01):73-83.

[54] Putnam JB Jr;Roth JA .Surgical treatment for pulmonary metastases from sarcoma.[J].Hematology Oncology Clinics of North America,1995(4):869-887.

[55] Rosen G;Tefft M;Martinez A et al.Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma[J].Cancer,1975,35(03):622-630.

[56] Rosenburg SA;Flye MW;Conklc D et al.Treatment of osteogenic sarcoma.Ⅱ.Aggressive resection of pulmonary metastascs[J].Cancer Treatment Reports,1979,63(05):753-756.

[57] Siegel HJ;Pressey JG .Current concepts on the surgical and medical management of osteosarcoma.[J].Expert review of anticancer therapy,2008(8):1257-1269.

[58] Marulanda GA;Henderson ER;Johnson DA;Letson GD;Cheong D .Orthopedic surgery options for the treatment of primary osteosarcoma.[J].Cancer control: journal of the Moffitt Cancer Center,2008(1):13-20.

[59] 张清,徐万鹏,郭卫,沈靖南,陶惠民,姚阳,毕文志,吴苏稼,张伟滨,杨蕴,于秀淳,李建民,郭征,徐绍年,熊进,朱兵,韦兴,杜心如,牛晓辉.我国骨肉瘤治疗现状及改进建议--17家骨肿瘤治疗中心1998~2008年资料分析[J].中国骨肿瘤骨病,2009(03):129-132.

[60] Nagarajan R;Weigel BJ;Thompson RC et al.Osteosarcoma in the first decade of life[J].Medical and Pediatric Oncology,2003,41(05):480-483.

[61] Ferrari S;Balladelli A;Palmerini E.Imaging in bone sarcomas.The chemotherapist's point of view[J/OL].European Journal of Radiology,2011

[62] Errani C;Kreshak J;Ruggieri P.Imaging of bone tumors for the musculoskeletal oncologic surgeon[J/OL].European Journal of Radiology,2011

[63] Eftckhari F .Imaging assessment of osteosarcoma in childhood and adolescence:diagnosis,staging,and evaluating response to chemotherapy[J].Cancer Treatment and Research,2009,152:33-62.

[64] Craft AW .Osteosarcoma:the European Osteosarcoma Intergroup (EOI) perspective[J].Cancer Treatment and Research,2009,152:263-274.

[65] Guo,J.;Reddick,W.E.;Glass,J.O.;Ji,Q.;Billups,C.A.;Wu,J.;Hoffer,F.A.;Kaste,S.C.;Jenkins,J.J.;OrtegaFlores,X.C.;Quintana,J.;Villarroel,M.;Daw,N.C. .Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival in pediatric patients with osteosarcoma[J].Cancer: A Journal of the American Cancer Society,2012(15):3776-3785.

[66] Wetzel LH;Levine E;Murphey MD .A comparison of MR imaging and CT in the evaluation of musculoskeletal masscs[J].Ra diographics,1987,7(05):851-874.

[67] Sundaram M;McGuire MH;Herbold DR .Magnetic resonance imaging of osteosarcoma[J].Skcletal Radiol,1987,16(01):23-29.

[68] Aisen AM;Martel W;Braunstein EM et al.MRI and CT evaluation of primary bone and soft-tissue tumors[J].American Journal of Roentgenology,1986,146(04):749-756.

[69] Meyer JS;Nadel HR;Marina N;Womer RB;Brown KL;Eary JF;Gorlick R;Grier HE;Randall RL;Lawlor ER;Lessnick SL;Schomberg PJ;Kailo MD .Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee.[J].Pediatric blood & cancer,2008(2):163-170.

[70] Reddick,WE;Wang,S;Xiong,X;Glass,JO;Wu,S;Kaste,SC;Pratt,CB;Meyer,WH;Fletcher,BD .Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma.[J].Cancer,2001(12):2230-2237.

[71] Sundaram M;McGuire MH;Herbold DR;ct al .Magnetic reso nance imaging in planning limb-salvage surgery for primary malignant tumors of bone[J].Journal of Bone and Joint Surgery-American Volume,1986,68(06):809-819.

[72] Wallack ST;Wisner ER;Werner JA;Walsh PJ;Kent MS;Fairley RA .Accuracy of magnetic resonance imaging for estimating intramedullary osteosarcoma extent in pre-operative planning of canine limb-salvage procedures[J].Veterinary radiology & ultrasound,2002(5):432-441.

[73] Pochanugool L;Subhadharaphandou T;Dhanachai M;Hathirat P;Sangthawan D;Pirabul R;Onsanit S;Pornpipatpong N .Prognostic factors among 130 patients with osteosarcoma.[J].Clinical Orthopaedics and Related Research,1997(345):206-214.

[74] Bacci G;Dallari D;Battistini A et al.The prognostic value of serum alkaline phosphatase in osteosarcoma of the limbs[J].Chir Organi Moy,1992,77(02):171-180.

[75] Bacci G;Picci P;Ferrari S et al.Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or ncoadjuvant chemotherapy[J].Cancer,1993,71(04):1224-1230.

[76] Kilpatrick SE;Ward WG;Bos GD et al.The role of fine nccdle aspiration biopsy in the diagnosis and management of osteosarcoma[J].Pediatric Pathol Mol Med,2001,20(03):175-187.

[77] Agarwal S;Agarwal T;Agarwal R et al.Finc needle aspiration of bone tumors[J].Cancer Detection and Prevention,2000,24(06):602-609.

[78] Ward WG Sr;Kilpatrick S .Fine needle aspiration biopsy of primary bone tumors[J].Clinical Orthopaedics and Related Research,2000,373:80-87.

[79] Nanda M;Rao ES;Behera KC et al.Fine needle aspiration cytology (FNAC) in malignant bonc tumours[J].Indian Journal of Pathology & Microbiology,1994,37(03):247-253.

[80] Raymond AK;Simms W;Ayala AG .Osteosarcoma. Specimen management following primary chemotherapy.[J].Hematology Oncology Clinics of North America,1995(4):841-867.

[81] Hudson TM;Schiebler M;Springfield DS et al.Radiologic imaging of osteosareoma:role in planning surgieal treatment[J].Skeletal Radiology,1983,10(03):137-146.

[82] Delling G;Krumme H;Salzer-Kuntschik M .Morphological changes in osteosarcoma after chcmothcrapy--COSS 80[J].Journal of Cancer Research and Clinical Oncology,1983,106(Suppl):32-37.

[83] Wolf RE;Enneking WF .The staging and surgery of musculoskeletal neoplasms.[J].The Orthopedic Clinics of North America,1996(3):473-481.

[84] Wunder JS;Healey JH;Davis AM et al.A comparison of staging systems for localized extremity soft tissue sarcoma[J].Cancer,2000,88(12):2721-2730.

[85] Ogura K;Goto T;Imanishi J.Neoadjuvant and adjuvant chemotherapy with modified mesna,adriamycin,ifosfamide,and decarbazine (MAID) regimen for adult high-grade non-small round cell soft tissue sarcomas[J/OL].Int J Clin Oneol,2011

[86] Machak GN;Tkachev SI;Solovyev YN;Sinyukov PA;Ivanov SM;Kochergina NV;Ryjkov AD;Tepliakov VV;Bokhian BY;Glebovskaya VV .Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities.[J].Mayo Clinic Proceedings,2003(2):147-155.

[87] Lowery MA;Cadoo K;Treacy A et al.Neoadjuvant ehemotherapy for adult osteosarcoma:Results of long term follow-up[J].Journal of Clinical Oncology,2008,26(15 Suppl):a10543.

[88] 全国骨肉瘤化疗座谈会纪要[J].中华骨科杂志,1999(01):7.

[89] 蔡槱伯,牛晓辉,张清.肢体原发成骨肉瘤综合治疗的远期结果[J].中华外科杂志,2000(05):329.

[90] Link MP;Goorin AM;Horowitz M et al.Adjuvant chemotherapy of high-grade osteosarcoma of the extremity.Updated results of the Multi-Institutional Osteosarcoma Study[J].Clinical Orthopaedics and Related Research,1991,270:8-14.

[91] Anninga,J.K.;Gelderblom,H.;Fiocco,M.;Kroep,J.R.;Taminiau,A.H.M.;Hogendoorn,P.C.W.;Egeler,R.M. .Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand?[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR),2011(16):2431-2445.

[92] Zalupski MM;Rankin C;Ryan JR et al.Adjuvant therapy of osteosarcoma--A Phase H trial:Southwest Oneology Group study 9139[J].Cancer,2004,100(04):818-825.

[93] Bacci G;Longhi A;Ferrari S;Mercuri M;Versari M;Bertoni F .Prognostic factors in non-metastatic Ewing's sarcoma tumor of bone: an analysis of 579 patients treated at a single institution with adjuvant or neoadjuvant chemotherapy between 1972 and 1998.[J].Acta Oncologica,2006(4):469-475.

[94] Bacci G;Picci P;Ferrari S et al.Primary chemotherapy and delayed surgery for non-metastatic tclangicctatic osteosarcoma of the extremities.Results in 28 patients[J].European Journal of Cancer,1994,30A(05):620-626.

[95] Bramwcll VH .The role of chemotherapy in the management of non-ntetastatic operable extremity ostcosarcoma[J].Semin On col,1997,24(05):561-571.

[96] Bush H .Adjuvant chemotherapy:an approach to the management of malignant disease[J].British Journal of Hospital Medicine,1978,20(03):260-275.

[97] Campanacci M;Bacei G;Bertoni F et al.The treatment of osteosarcoma of the extremities:twenty year 's experience at the Istituto Ortopedico Rizzoli[J].Cancer,1981,48(07):1569-1581.

[98] Cortes EP;Holland JF .Adjuvant chemotherapy for primary osteogenic sacoma[J].Surgical Clinics of North America,1981,61(06):1391-1404.

[99] Craft AW;Machin D;Souhami RL .Adjuvant chemotherapy for non-metastatic osteosarcoma of the extremities in two New Zealand cancer centres[J].Australian & New Zealand Journal of Medicine,1996,26(02):230.

[100] Donaldson SS .The value of adjuvant chemotherapy in the managcment of sarcomas in children[J].Cancer,1985,55(9 Suppl):2184-2197.

[101] Eilber F;Giuliano A;Eekardt J et al.Adjuvant chemotherapy for osteosarcoma:a randomized prospective trial[J].Journal of Clinical Oncology,1987,5(01):21-26.

[102] Eilber FR;Rosen G .Adjuvant chemotherapy for osreosarcoma[J].Seminars in Oncology,1989,16(04):312-322.

[103] Frei E 3rd;Jaffe N;Gero M et al.Adjuvant chemotherapy of osteogenic sarcoma:progress and perspectives[J].Journal of the National Cancer Institute,1978,60(01):3-10.

[104] Goorin AM;Frei E 3rd;Abelson HT .Adjuvant chemotherapy for osteosarcoma:a decade of experience[J].Surgical Clinics of North America,1981,61(06):1379-1389.

[105] Hazan,EJ;Hornicek,FJ;Tomford,W;Gebhardt,MC;Mankin,HJ .The effect of adjuvant chemotherapy on osteoarticular allografts.[J].Clinical Orthopaedics and Related Research,2001(385):176-181.

[106] Jaffe N .Adjuvant chemotherapy in osteosarcoma:an odyssey of rejection and vindication[J].Cancer freat Res,2009,152:219-237.

[107] Jaffe N;Smith D;Jaffe MR et al.Intraarterial cisplatin in the management of stage IIB osteosarcoma in the pediatric and adolescent age group[J].Clinical Orthopaedics and Related Research,1991,270:15-21.

[108] Winkler K;Beron G;Kotz R et al.Adjuvant chemotherapy in osteosarcoma-effects of cisplatinum,BCD,and fibroblast intcrferon in sequential combination with HD-MTX and adriamyein.Preliminary results of the COSS 80 study[J].Journal of Cancer Research and Clinical Oncology,1983,106(Suppl):1-7.

[109] Rosen G;Marcove RC;Huvos AG et al.Primary osteogenic sarcoma:eight-year experience with adjuvant chemotherapy[J].Journal of Cancer Research and Clinical Oncology,1983,106(Suppl):55-67.

[110] Meyers PA;Heller G;Healey J et al.Chemotherapy for nonmetastatic osteogenic sarcoma:the Memorial Sloan-Kettering experience[J].Journal of Clinical Oncology,1992,10(01):5-15.

[111] Rosen G;Marcove RC;Caparros B et al.Primary osteogenic sarcoma:the rationale for preoperative chemothcrapy and delayed surgery[J].Cancer,1979,43(06):2163-2177.

[112] Bielack SS;Kempf Bielack-B;Heise U;Schwenzer D;Winkler K .Combined modality treatment for osteosarcoma occurring as a second malignant disease. Cooperative German-Austrian-Swiss Osteosarcoma Study Group.[J].Journal of Clinical Oncology,1999(4):1164-0.

[113] Bacci G;Briccoli A;Ferrari S et al.Neoadjuvant chemotherapy for osteosarcoma of the extremity:long-term results of the Rizzoli 's 4th protocol[J].European Journal of Cancer,2001,37(16):2030-2039.

[114] Bacci,G;Ferrari,S;Mercuri,M;Longhi,A;Capanna,R;Tienghi,A;Brach-del-Prever,A;Comandone,A;Cesari,M;Bernini,G;Picci,P .Neoadjuvant chemotherapy for extremity osteosarcoma--preliminary results of the Rizzoli's 4th study.[J].Acta Oncologica,1998(1):41-48.

[115] Goorin AM;Schwartzentruber DJ;Devidas M;Gebhardt MC;Ayala AG;Harris MB;Helman LJ;Grier HE;Link MP .Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.[J].Journal of Clinical Oncology,2003(8):1574-1580.

[116] Bacci G;Balladelli A;Palmerini E;Alberghini M;Pollastri P;Galletti S;Mercuri M;Picci P .Neoadjuvant chemotherapy for osteosarcoma of the extremities in preadolescent patients: the Rizzoli Institute experience.[J].Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology,2008(12):908-912.

[117] Bacci G;Bertoni F;Longhi A;Ferrari S;Forni C;Biagini R;Bacchini P;Donati D;Manfrini M;Bernini G;Lari S .Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity.[J].Cancer,2003(12):3068-3075.

[118] Bacci G;Briccoli A;Rocca M;Ferrari S;Donati D;Longhi A;Bertoni F;Bacchini P;Giacomini S;Forni C;Manfrini M;Galletti S .Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide.[J].Annals of oncology: official journal of the European Society for Medical Oncology,2003(7):1126-1134.

[119] Bacci G;Ferrari S;Bertoni F;Donati D;Bacchini P;Longhi A;Brach Del-Prever-A;Forni C;Rimondini S .Neoadjuvant chemotherapy for peripheral malignant neuroectodermal tumor of bone: recent experience at the istituto rizzoli.[J].Journal of Clinical Oncology,2000(4):885-892.

[120] Bacci C;Ferrari S;Bertoni F et al.Neoadjuvant chemotherapy for osseous malignant fibrous histiocytoma of the extremity:results in 18 cases and comparison with 112 contemporary ostcosarcoma patients treated with the same chemotherapy regimen[J[J].Journal of Chemotherapy,1997,9(04):293-299.

[121] Bacci G;Ferrari S;Longhi A et al.Relationship between doseintensity of treatment and outcome for patients with osteosarcoma of the extremity treated with neoadjuvant chcmotherapy[J].Oncology Reports,2001,8(04):883-888.

[122] Bacci C;Forni C;Ferrari S et al.Neoadjuvant chemotherapy for osteosarcoma of the extremity:intensification of preoperative treatment does not increase the rate of good histologic response to the primary tumor or improve the final outeome[J].J Pediatr Hcmatol Oncol,2003,25(11):845-853.

[123] Bacci G;Lari S .Adjuvant and neoadjuvant chemotherapy in osteosarcma[J].Chirurgia Degli Organi Di Movimento,2001,86(04):253-268.

[124] Bacci G;Longhi A;Forni C;Fabbri N;Briccoli A;Barbieri E;Mercuri M;Balladelli A;Ferrari S;Picci P .Neoadjuvant chemotherapy for radioinduced osteosarcoma of the extremity: The Rizzoli experience in 20 cases.[J].International Journal of Radiation Oncology, Biology, Physics,2007(2):505-511.

[125] Bacci G;Mercuri M;Longhi A et al.Neoadjuvant chemothcrapy for the treatment of ostcosarcoma of the extrcmities:a comparison of results obtained in single-institution and multicenter trials[J].Chirurgia Degli Organi Di Movimento,2004,89(04):283-292.

[126] Bacci G;Mercuri M;Ruggieri P et al.Neoadjuvant chemotherapy for malignant fibrous histiocytoma of bone and for osteosarcoma of the limbs:a comparison between the results obtained for 21 and 144 patients,respectively,treated during the same period with the same chemotherapy protocol[J].Chirurgia Degli Organi Di Movimento,1996,81(02):139-153.

[127] Bacci G;Picci P;Ferrari S et al.Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities:the recent experience at the Rizzoli Institute[J].Cancer Treatment and Research,1993,62:299-308.

[128] Bacci G;Picci P;Ferrari S et al.Neoadjuvant chemotherapy for the treatment of osteosarcoma of the extremities:excellent response of the primary tumor to preoperative treatment with methotrexate,cisplatin,adriamycin,and ifosfamide.Preliminary results[J].Chirurgia Degli Organi Di Movimento,1995,80(01):1-10.

[129] Bacci G;Picci P;Ruggieri P et al.Neoadjuvant chemotherapy for the treatment of osteosareoma of the limhs.Preliminary results in 100 patients treated preoperatively with high doses of methotrexate i.v.followed by cisplatin (i.a.)and adriamycin[J].Chirurgia Degli Organi Di Movimento,1991,76(01):1-16.

[130] Cassano WF;Graham-Pole J;Dickson N .Etoposide,cyclophosphamide,cisplatin,and doxorubicin as neoadjuvant chemotherapy for osteosarcoma[J].Cancer,1991,68(09):1899-1902.

[131] Graham-Pole J;Ayass M;Cassano W et al.Neoadjuvant chemotherapy for patients with osteosarcoma:University of Florida studies[J].Cancer Treatment and Research,1993,62:339-346.

[132] Nakano H;Tateishi A;Imamura T et al.Intensive preoperative chemotherapy for osteosarcoma in the lower extremity[J].Anticancer Research,1998,18(4B):2859-2864.

[133] Uchida A;Myoui A;Araki N et al.Neoadjuvant chemotherapy for pediatric osteosarcoma patients[J].Cancer,1997,79(02):411-415.

[134] Wada T;Isu K;Takeda N et al.A preliminary report of neoadjuvant chemotherapy NSH-7 study in osteosarcoma:preoperative salvage chemotherapy based on clinical tumor response and the use of granulocyte colony-stimulating factor[J].Oncology(Basel),1996,53(03):221-227.

[135] Wynendaele W;van Oosterom AT .Neoadjuvant/primary chemotherapy in cancer treatment:what advantage[J].Forum(Genova),1999,9(03):212-221.

[136] 郭卫,杨荣利,汤小东,唐顺,李大森,杨毅.成骨肉瘤新辅助化学药物治疗的疗效分析[J].中华医学杂志,2004(14):1186-1190.

[137] 王臻,黄耀添,黄鲁豫,赵金康,于会东,刘继中,杜晓川,李敬帮,晏培松,王志祥.高危骨肉瘤的临床特点及治疗对策[J].第四军医大学学报,2002(05):465-468.

[138] 牛晓辉,蔡槱伯,张清,郝林,丁易.ⅡB期肢体骨肉瘤189例综合治疗临床分析[J].中华外科杂志,2005(24):1576-1579.

[139] Uchida A;Myoui A;Araki N et al.Neoadjuvant chemotherapy for pediatric osteosareoma patients[J].Cancer,1997,79(02):411-415.

[140] Wittig JamesC;ol.com;Bickels Jacob;Priebat Dennis;Jelinek James;Kellar-Graney Kristen;Shmookler Barr;Malawer MartinM .Osteosarcoma: a multidisciplinary approach to diagnosis and treatment.[J].American Family Physician,2002(6):1123-1132.

[141] Bielack S;Jürgens H;Jundt G.Pediatric and adolescent osteosarcoma[M].Springer US,2010:125-145.

[142] Bacci G;Picci P;Ruggieri P et al.Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities.The Istituto Rizzoli Experience in 127 patients treated prcoperatively with intravenous methotrexate (high versus moderate doses) and intraartcrial cisplatin[J].Cancer,1990,65(11):2539-2553.

[143] Scully SP;Temple HT;O'Keefe RJ;Mankin HJ;Gebhardt M .The surgical treatment of patients with osteosarcoma who sustain a pathologic fracture.[J].Clinical Orthopaedics and Related Research,1996(324):227-232.

[144] Ferrari S;Palmerini E;Staals EL et al.The treatment of nonmetastatic high gradc osteosarcoma of the extremity:rcview of the Italian Rizzoli expcrience.Impact on the futurc[J].Cancer Treatment and Research,2009,152:275-287.

[145] Bacci G;Ferrari S;Longhi A et al.Pattern of relapse in patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy[J].European Journal of Cancer,2001,37(01):32-38.

[146] Oner Dincbas F;Koca S;Molinas Mandel N;Hiz M;Dervisoglu S;Secmezacar H;Colpan Oksuz D;Ceylaner B;Uzel B .The role of preoperative radiotherapy in nonmetastatic high-grade osteosarcoma of the extremities for limb-sparing surgery.[J].International Journal of Radiation Oncology, Biology, Physics,2005(3):820-828.

[147] 牛晓辉.恶性骨肿瘤外科治疗的术前计划及术后评估[J].中华外科杂志,2007(10):699-701.

[148] Lascelles BD;Dernell WS;Correa MT;Lafferty M;Devitt CM;Kuntz CA;Straw RC;Withrow SJ .Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma.[J].Annals of surgical oncology,2005(12):1073-1083.

[149] Li,J.;Wang,Z.;Guo,Z.;Chen,G.-J.;Yang,M.;Pei,G.-X. .Irregular osteotomy in limb salvage for juxta-articular osteosarcoma under computer-assisted navigation[J].Journal of Surgical Oncology,2012(4):411-416.

[150] Kawaguchi N;Ahmed AR;Matsumoto S;Manabe J;Matsushita Y .The concept of curative margin in surgery for bone and soft tissue sarcoma.[J].Clinical Orthopaedics and Related Research,2004(419):165-172.

[151] Fitzhugh CD;Wise B;Baird K;Tsokos M;Helman L;Mackall C;Savage SA;Warren KE .Secondary supratentorial primitive neuroectodermal tumor following treatment of childhood osteosarcoma.[J].Pediatric blood & cancer,2009(3):496-498.

[152] Ferrari S;Bacci G;Picci P et al.Long-term follow-up and postrelapse survival in patients with non-metastatic osteosarcoma of the extremity treated with neoadjuvant chemotherapy[J].Annals of Oncology,1997,8(08):765-771.

[153] Bielack SS;Marina N;Ferrari S et al.Osteosarcoma:the same old drugs or more[J].Journal of Clinical Oncology,2008,26(18):3102-3103.

[154] 孙燕.肿瘤药物治疗百年回顾与展望[J].中华肿瘤杂志,2004(11):701-703.

[155] 孙燕.临床肿瘤50年:创新中发展[J].医学研究杂志,2010(04):1-3.


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关键词经典型骨肉瘤 诊断 治疗 共识


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