内源性MAO-B抑制因子-靛红预防MPTP对多巴胺神经递质的耗竭作用

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1青岛大学医学院药理教研室,山东,青岛,266021

2香川医科大学药理学讲座,高松761-0793,日本


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研究内源性单胺氧化酶B抑制因子-靛红(2,3-吲哚醌,isatin)对MPTP引起的小鼠纹状体DA含量降低的影响.用高效液相色谱配电化学检测器测定纹状体DA,DOPAC和HVA水平.MPTP 30 mg/kg ip使纹状体DA,DOPAC和HVA含量与各自对照组比较显著降低(P<0.01),预先靛红(200mg/kg@d,×4 d,ig)几乎完全抑制了上述效应,并减少了MPTP对DA更新率的升高,说明靛红有预防MPTP对中枢DA能神经元的毒性.

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语种: 英文   

基金国家自然科学基金(30076867)

关键词单胺氧化酶B抑制因子 靛红 多巴胺 1-甲基-4-苯基-1,2,3,6-四氢吡啶


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